Some puppies in the field may have higher levels of maternal antibodies than those evaluated in our pivotal efficacy study. The CPV fraction is high titer (>10 7.0 TCID 50/dose) and was attenuated by low passage (35 passes from the canine isolate with a maximum of 2 additional passes allowed for production) in the canine cell line which gives it the immunogenic properties capable of overriding maternal antibody interference at the levels indicated below. Vanguard Plus 5 contains attenuated strains of CD virus, CAV-2, CPI virus, and CPV propagated in an established canine cell line. PRODUCT DESCRIPTION: Vanguard Plus 5 is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, and canine parvoviral enteritis caused by canine parvovirus (CPV). Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine
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